Side effects can include hypokalemia, increased serum cholesterol, impaired glucose tolerance, diabetes mellitus and impotence. The side effect of hypokalemia has motivated combining thiazides with potassium chloride supplementsAdh30 (talk) 16:24, 25 April 2008 (UTC), potassium sparing diuretics (eg with amiloride in co-amilozide) and with the newer ACE inhibitors, which also lower blood pressure but cause hyperkalemia as a side effect.

Long-term usage of thiazides is also linked to increased levels of homocysteine, a toxic amino acid byproduct, that has been associated with atherosclerosis but there is no evidence that people receiving long-term thiazide treatments should also receive folic acid supplements. They have been known to cause a paradoxical effect in Diabetes insipidus, where they reduce the volume of urine. Thiazide diuretics are capable of inhibiting urate secretion.

Other uses
Thiazides also lower urinary calcium excretion, making them useful in preventing calcium-containing kidney stones. This effect is associated with positive calcium balance and is associated with an increase in bone mineral density and reductions in fracture rates attributable to osteoporosis. By a lesser understood mechanism, thiazides directly stimulate osteoblast differentiation and bone mineral formation, further slowing the course of osteoporosis.

Because of their promotion of calcium retention, thiazides are used in the treatment of Dent's Disease or idiopathic hypercalciuria.

Thiazide may be combined with ACE inhibitors to increase diuresis without changing plasma potassium concentrations. While ACE inhibitors cause diuresis with potassium retention, thiazide increases potassium excretion. Their combined effects on potassium cancel each other out.

Quinapril drug information Cardiac glycoside Pharmacodynamics and clinical effects Thiazide side effects Phytosterols Mechanisms of hypokalemia Indications and usage Inhibitor effects Cardenolides Adverse effects Thiazide Digoxin Warnings Inhibitor adverse effects Clinical pharmacology Ace inhibitor Digoxin clinical use Quinapril faq Precautions Steroid